2-（取代苯基）-5-（2,3-二氢-1,4-苯并二恶烷-2-基）-1,3,4-恶二唑衍生物的合成及抗肝毒性活性。
Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives.
机构信息
Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India.
出版信息
J Enzyme Inhib Med Chem. 2011 Apr;26(2):216-21. doi: 10.3109/14756366.2010.489899. Epub 2010 Jul 1.
Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl₄-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.
新型 1,3,4-恶二唑衍生物含有 1,4-二氧六环环系统，是从 2,3-二氢-1,4-苯并二恶烷-2-甲酰肼出发合成的。合成的化合物进行了抗 CCl₄ 诱导的大鼠肝毒性的抗肝毒性活性评价。一些化合物表现出显著的抗肝毒性活性，可与标准药物水飞蓟素相媲美。
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