Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Am J Health Promot. 2010 Jul-Aug;24(6):378-83. doi: 10.4278/ajhp.080826-QUAN-161.
To address the translational research question regarding the optimal intervention "dose" to produce the most cost-effective rate of weight loss, we conducted the Drop It At Last (DIAL) study.
DIAL is a 6-month pilot randomized trial to examine the efficacy of phone-based weight loss programs with varying levels of treatment contact (10 vs. 20 sessions) in comparison to self-directed treatment.
Participants were recruited from the community via mailings and advertisement.
Participants were 63 adults with a body mass index between 30 and 39 kg/m(2).
Participants received a standard set of print materials and were randomized to either: (1) self-directed treatment; (2) 10 phone coaching sessions; or (3) 20 phone coaching sessions.
Measured height, weight, and psychosocial and weight-related self-monitoring measures were collected at baseline and follow-up.
General linear models were used to examine 6-month treatment group differences in weight loss and in psychosocial and behavioral measures.
Weight losses were -2.3, -3.2, and -4.9 kg in the self-directed, 10-session, and 20-session groups, respectively (p < .21). Participants who completed 10 or more sessions lost more weight (-5.1 kg) compared to those completed four or fewer sessions (-.3 kg, p < .04).
Phone-based weight loss program participation is associated with modest weight loss. The optimal dose and timing of intervention warrant further study.
为了解决关于产生最具成本效益减肥率的最佳干预“剂量”的转化研究问题，我们进行了 Drop It At Last（DIAL）研究。
DIAL 是一项为期 6 个月的试点随机试验，旨在比较基于电话的减肥计划的疗效，这些计划的治疗接触程度不同（10 次与 20 次），与自我指导治疗相比。
参与者通过邮件和广告从社区招募。
参与者为 63 名身体质量指数在 30 至 39kg/m²之间的成年人。
参与者收到一套标准的印刷材料，并随机分为以下三组：（1）自我指导治疗；（2）10 次电话辅导课程；或（3）20 次电话辅导课程。
在基线和随访时测量身高、体重以及心理社会和体重相关的自我监测指标。
使用一般线性模型来检验 6 个月治疗组在减肥以及心理社会和行为措施方面的差异。
自我指导组、10 次会话组和 20 次会话组的体重分别减轻了 2.3kg、3.2kg 和 4.9kg（p<0.21）。完成 10 次或更多会话的参与者比完成 4 次或更少会话的参与者体重减轻更多（-5.1kg 与-.3kg，p<0.04）。
基于电话的减肥计划参与与适度的体重减轻有关。干预的最佳剂量和时机需要进一步研究。
