Tigges M, Tigges J
Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322.
Vis Neurosci. 1991 Apr;6(4):375-82. doi: 10.1017/s095252380000660x.
Immunocytochemical methods with antiserum to the calcium-binding protein parvalbumin (PV) were used to examine the effects of monocular enucleation on parvalbuminergic neurons and processes in the lateral geniculate nucleus (LGN) of adult rhesus monkeys. In the LGN of normal monkeys, numerous PV-positive neurons, including the largest neurons in the nucleus, and many PV-positive processes occur in all six laminae. After monocular enucleation, PV immunoreactivity is reduced in the neuropil of the denervated laminae compared to adjacent nondenervated and to normal laminae. PV immunoreactivity of somata in denervated laminae, however, appears to be indistinguishable from that of somata in nondenervated laminae, although neurons in the denervated laminae are smaller in size. Since LGN neurons in denervated laminae have lost their visual input, the functional role of PV in this nucleus may not relate directly to visual information processing.
采用抗钙结合蛋白小白蛋白（PV）抗血清的免疫细胞化学方法，研究了单眼摘除对成年恒河猴外侧膝状体（LGN）中小白蛋白能神经元及突起的影响。在正常猴子的LGN中，所有六层均有大量PV阳性神经元，包括核内最大的神经元，以及许多PV阳性突起。单眼摘除后，与相邻未去神经支配的层和正常层相比，去神经支配层的神经毡中PV免疫反应性降低。然而，去神经支配层中神经元胞体的PV免疫反应性似乎与未去神经支配层中神经元胞体的PV免疫反应性没有区别，尽管去神经支配层中的神经元尺寸较小。由于去神经支配层中的LGN神经元失去了视觉输入，PV在该核中的功能作用可能与视觉信息处理没有直接关系。
