[葡萄膜炎揭示的伴有抗髓过氧化物酶胞浆型抗中性粒细胞胞浆抗体的韦格纳肉芽肿病]

[Wegener's granulomatosis with anti-MPO c-ANCA revealed by uveitis].

作者信息

Mbéthé G L Gaundong, Diéval C, Lafitte A, Roger-Schmeltz J, Longy-Boursier M, Mercié P

机构信息

Service de médecine interne et maladies tropicales, pôle médecine urgences, hôpital Saint-André, université Victor-Segalen-Bordeaux-2, 33075 Bordeaux cedex, France.

出版信息

Rev Med Interne. 2010 Oct;31(10):e11-3. doi: 10.1016/j.revmed.2009.10.438. Epub 2010 Jun 3.

DOI:10.1016/j.revmed.2009.10.438

PMID:20605280

Abstract

Wegener's granulomatosis (WG) is a rare systemic necrotizing granulomatous vasculitis affecting small- to medium-sized vessels, associated with antineutrophil cytoplasm antibodies (ANCA), mainly anti-proteinase 3. Rarely, ANCA may be directed against myeloperoxidase. We report a 58-year-old woman who developed an uveitis as the presenting manifestation of Wegener's granulomatosis who highlight the usefulness of internist and ophthalmologist collaboration.

摘要

韦格纳肉芽肿（WG）是一种罕见的系统性坏死性肉芽肿性血管炎，累及中小血管，与抗中性粒细胞胞浆抗体（ANCA）相关，主要是抗蛋白酶3。罕见情况下，ANCA可能针对髓过氧化物酶。我们报告了一名58岁女性，她以葡萄膜炎作为韦格纳肉芽肿的首发表现，强调了内科医生和眼科医生合作的实用性。