激肽释放酶-激肽系统：阿替普酶时代的手术视角。

Kallikrein-kinin system: a surgical perspective in post-aprotinin era.

机构信息

School of Surgery, University of Western Australia, Perth, Australia.

出版信息

J Surg Res. 2011 May 1;167(1):70-7. doi: 10.1016/j.jss.2009.12.020. Epub 2010 Jan 15.

DOI:10.1016/j.jss.2009.12.020

PMID:20605589

Abstract

Kallikrein-kinin system (KKS) plays an important role in inflammation, ischemia-reperfusion (IR) injury, and development of neoplasia. There is evidence to suggest that KKS plays an important role in organ protection during preconditioning. Aprotinin is a nonspecific serine protease inhibitor, which has been extensively used in cardiac surgery for the control of post operative bleeding. The anti-inflammatory effects of aproprotin are due to its inhibitory effect on the kallikrein-kinin system (KKS). We herein review KKS and its role as applied to the practice of surgery.

摘要

激肽释放酶-激肽系统（KKS）在炎症、缺血再灌注（IR）损伤和肿瘤发生发展中发挥重要作用。有证据表明，KKS 在预处理过程中对器官保护起着重要作用。抑肽酶是一种非特异性丝氨酸蛋白酶抑制剂，在心脏手术中广泛用于控制术后出血。抑肽酶的抗炎作用归因于其对激肽释放酶-激肽系统（KKS）的抑制作用。本文综述了 KKS 及其在外科实践中的作用。