Salovich James M, Lindsley Craig W, Hopkins Corey R
Department of Pharmacology and Vanderbilt Program in Drug Discovery.
Tetrahedron Lett. 2010 Jul 21;51(29):3796-3799. doi: 10.1016/j.tetlet.2010.05.060.
Herein we report a general synthesis of 1,3-diarylsubstituted indazoles utilizing a two-step Suzuki cross-coupling/deprotection/N-arylation sequence. This procedure proceeds in excellent overall yield starting from the 3-iodo-N-Boc indazole derivative allowing for rapid access to these compounds.
在此,我们报道了一种通过两步铃木交叉偶联/脱保护/N-芳基化序列来合成1,3-二芳基取代吲唑的通用方法。该方法从3-碘-N-Boc吲唑衍生物开始,以优异的总收率进行,能够快速获得这些化合物。