Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
J Headache Pain. 2010 Oct;11(5):379-89. doi: 10.1007/s10194-010-0232-1. Epub 2010 Jul 7.
Calculating verisimilitude (or "truthlikeness") ad modum Popper is a quantitative alternative to the usual pros and cons in migraine and cluster headache mechanisms. The following items were evaluated: dilation of large cranial arteries during migraine; CGRP increase during migraine; migraine as a brain disorder; aura and migraine headache; brain stem activation during migraine; rCBF in migraine without aura; NO and pathophysiology of migraine; neurogenic inflammation and migraine; aura in cluster headache; and hypothalamic activation in cluster headache. It is concluded that verisimilitude calculations can be helpful when judging pathophysiological problems in migraine and cluster headache.
按照波普尔的模式计算逼真度(或“似真性”)是偏头痛和丛集性头痛机制中常用的利弊的定量替代方法。评估了以下项目:偏头痛期间的颅大血管扩张;偏头痛期间 CGRP 的增加;偏头痛作为一种大脑疾病;先兆和偏头痛头痛;偏头痛期间的脑干激活;无先兆偏头痛的 rCBF;NO 和偏头痛的病理生理学;神经源性炎症和偏头痛;丛集性头痛中的先兆;以及丛集性头痛中的下丘脑激活。结论认为,逼真度计算在判断偏头痛和丛集性头痛的病理生理问题时可能会有所帮助。