National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230029, PR China.
J Mass Spectrom. 2010 Jul;45(7):734-9. doi: 10.1002/jms.1763.
Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (IR LD/VUV PIMS) and theoretical calculations. Mass spectra of the two drugs were measured at various photon energies. Fragment ions were gradually produced as photon energy increases. The structural assignment of the dominant fragment ions was supported by the results from a commercial electron impact time-of-flight mass spectrometer (EI-TOF MS). Primary fragmentation pathways were established from experimental observations combining with theoretical calculations. Methyl radical elimination is a common fragmentation pathway for two analytes. However, for propyphenazone cation, isopropyl group elimination to form antipyrine cation is another competitive pathway.
两种解热镇痛药，安替比林和丙基苯并噻嗪，采用红外激光解吸/可调谐同步辐射真空紫外光（VUV）光电离质谱（IR LD/VUV PIMS）和理论计算进行了研究。在不同的光子能量下测量了两种药物的质谱。随着光子能量的增加，逐渐产生碎片离子。通过商业电子碰撞飞行时间质谱仪（EI-TOF MS）的结果，支持了主要碎片离子的结构归属。从实验观察结合理论计算确定了主要的断裂途径。甲基自由基消除是两种分析物的常见断裂途径。然而，对于丙基苯并噻嗪阳离子，异丙基基团消除形成安替比林阳离子是另一种竞争途径。
