Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.
J Psychiatr Res. 2011 Feb;45(2):162-8. doi: 10.1016/j.jpsychires.2010.05.011. Epub 2010 Jun 2.
In this study, we assessed the oxidative stress parameters in rats submitted to an animal model of mania induced by ouabain (OUA), which included the use of lithium (Li) and valproate (VPA). Li and VPA treatment reversed and prevented the OUA-induced damage in these structures, however, this effect varies depending on the brain region and treatment regimen. Moreover, the activity of the antioxidant enzymes, namely, superoxide dismutase (SOD) and catalase (CAT) was found to be increased and decreased, respectively, in the brain of OUA-administered rats. Li and VPA modulated SOD and CAT activities in OUA-subjected rats in both experimental models. Our results support the notion that Li and VPA exert antioxidant-like properties in the brain of rats submitted to animal model of mania induced by ouabain.
在这项研究中，我们评估了大鼠在哇巴因（OUA）诱导的躁狂动物模型中的氧化应激参数，其中包括使用锂（Li）和丙戊酸（VPA）。Li 和 VPA 治疗逆转并预防了这些结构中 OUA 诱导的损伤，但这种作用因脑区和治疗方案而异。此外，发现给予 OUA 的大鼠的抗氧化酶（超氧化物歧化酶（SOD）和过氧化氢酶（CAT））的活性分别增加和减少。Li 和 VPA 在两种实验模型中调节了 OUA 给药大鼠的 SOD 和 CAT 活性。我们的结果支持这样的观点，即 Li 和 VPA 在大鼠的脑中发挥抗氧化样特性，这些大鼠被置于哇巴因诱导的躁狂动物模型中。
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