窖蛋白调节神经元细胞内信号转导。
Caveolin regulation of neuronal intracellular signaling.
机构信息
Department of Neuroscience, University of Minnesota, Minneapolis, 5455, USA.
出版信息
Cell Mol Life Sci. 2010 Nov;67(22):3785-95. doi: 10.1007/s00018-010-0447-y. Epub 2010 Jul 15.
Abstract
Caveolin proteins physically interact with and compartmentalize membrane-localized signaling proteins to facilitate high-fidelity intracellular signaling. Though primarily studied outside the nervous system, recent investigations have revealed that caveolin proteins are key modulators of a variety of neuronal intracellular signaling pathways. Through both protein aggregation and segregation, caveolin proteins can exert positive and negative influences on intracellular signaling. This review will detail recent findings regarding caveolin function in the brain.
摘要
窖蛋白蛋白与膜定位信号蛋白物理相互作用并分隔它们，以促进高保真的细胞内信号传递。尽管窖蛋白蛋白主要在神经系统外进行研究，但最近的研究表明，窖蛋白蛋白是多种神经元细胞内信号通路的关键调节因子。通过蛋白聚集和分隔，窖蛋白蛋白可以对细胞内信号传递产生正向和负向的影响。本文将详细介绍窖蛋白蛋白在大脑中的功能的最新发现。
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