舌下腺肿瘤：单中心 13 例患者的临床、病理和治疗分析。
Sublingual gland tumors: clinical, pathologic, and therapeutic analysis of 13 patients treated in a single institution.
机构信息
Department of Surgery, Head and Neck Surgery Service, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
出版信息
Head Neck. 2011 Apr;33(4):476-81. doi: 10.1002/hed.21469.
BACKGROUND
Sublingual gland tumors are rare, although frequently malignant. This study describes the clinicopathologic features and treatment results and reviews the literature.
METHODS
Thirteen cases treated between 1996 and 2007 were reviewed with interest on clinical, pathologic, and therapeutic information. Survival data were calculated by the Kaplan-Meier method.
RESULTS
Malignancies represented 92.3% of cases. Adenoid cystic carcinoma was the most common malignant type (66.7%). Most patients (83.3%) presented in advanced pathologic TNM stages (III or IV). All cases underwent surgical treatment. Neck dissection was performed in 69.2% with no metastases detected. Ten patients (83.3%) had adjuvant radiotherapy. Distant metastases occurred in 3 patients (25%). The 5-year overall and disease-free survival rates were 78.7% and 87.5%, respectively.
CONCLUSIONS
Tumors of the sublingual gland are rare and are usually malignant. Radical surgery and adjuvant radiotherapy seems to offer adequate local and regional control. Unlike distant failure, local recurrence and regional metastases are not common.
背景
舌下腺肿瘤虽罕见，但多为恶性。本研究旨在描述其临床病理特征和治疗结果，并复习文献。
方法
回顾性分析 1996 年至 2007 年间收治的 13 例患者的临床、病理和治疗资料。采用 Kaplan-Meier 法计算生存率。
结果
恶性肿瘤占 92.3%。最常见的恶性肿瘤类型是腺样囊性癌（66.7%）。83.3%的患者处于较晚的病理分期（III 或 IV 期）。所有患者均接受了手术治疗，69.2%的患者行颈淋巴结清扫术，未发现转移。10 例（83.3%）患者接受了辅助放疗。3 例（25%）患者发生远处转移。5 年总生存率和无病生存率分别为 78.7%和 87.5%。
结论
舌下腺肿瘤罕见，多为恶性。根治性手术和辅助放疗可提供充分的局部和区域控制。与远处失败不同，局部复发和区域转移并不常见。
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