Department of Renal Medicine, University of Queensland at the Princess Alexandra Hospital, Queensland, Australia.
Nephrology (Carlton). 2010 Aug;15(5):522-32. doi: 10.1111/j.1440-1797.2010.01349.x.
Advances in immunosuppressive therapies have improved kidney transplant outcomes. However, immunosuppressant drug-induced toxicities continue to reduce tolerability and impact patient and graft survival. A major ongoing challenge in kidney transplantation is to establish ways of tailoring immunosuppressant therapy so as to maintain efficacy while minimizing toxicity. Pharmacodynamic monitoring by direct measurement of immune cell function has the potential to personalize immunosuppression. The purpose of this review is to provide the clinician with an overview of the methodology and use of immune function monitoring in the field of kidney transplantation.
免疫抑制治疗的进展改善了肾移植的结果。然而，免疫抑制剂药物诱导的毒性继续降低了耐受性，并影响患者和移植物的存活。在肾移植中，一个主要的持续挑战是建立定制免疫抑制治疗的方法，以保持疗效，同时最大限度地减少毒性。通过直接测量免疫细胞功能进行药效学监测有可能实现免疫抑制的个体化。本综述的目的是为临床医生提供在肾移植领域免疫功能监测的方法学和应用概述。
