与曲坦类药物在慢性偏头痛中的疗效和过度使用相关的遗传多态性。
Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine.
机构信息
Department of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, Rome, Italy.
出版信息
J Headache Pain. 2010 Oct;11(5):431-5. doi: 10.1007/s10194-010-0241-0. Epub 2010 Jul 22.
Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein β3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.
偏头痛是一种常见的头痛类型，其最严重的发作通常采用曲普坦类药物治疗，但其疗效差异极大。已有研究描述了参与代谢和曲普坦类药物作用靶点的基因中的多个单核苷酸多态性。为了明确遗传特征与曲普坦类药物反应之间的相关性，我们根据曲普坦类药物的反应将偏头痛患者进行分类，并对编码单胺氧化酶 A、G 蛋白β3 和细胞色素 CYP1A2 的基因中的多态性进行了特征描述。对分析的 SNP 的基因型和等位基因频率与曲普坦类药物给药反应程度之间的相关性分析显示，MAOA uVNTR 多态性与曲普坦类药物的过度使用呈显著相关，并且在滥用者中，与 CYP1A2*1F 变异体的药物反应呈显著相关。
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