Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cell Adh Migr. 2010 Oct-Dec;4(4):561-6. doi: 10.4161/cam.4.4.12829.
Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryonic development. One of these migratory cell populations is the neural crest, which forms cranial bone and mesenchyme, sympathetic neurons and ganglia, melanocytes, and smooth muscle. Mice with disruption of PDGF signaling exhibit defects in some of these neural crest derivatives including the palate, aortic arch, salivary gland, and thymus. Although many of these neural crest defects were identified many years ago, the mechanism of action of PDGF in neural crest remains controversial. In this review, we examine the current knowledge of PDGF function during neural crest cell (NCC) development, focusing on its role in the formation of different neural crest-derived tissues and the implications for PDGF receptors in NCC-related human birth defects.
血小板衍生生长因子（PDGF）受体的激活会引起细胞的应答，包括增殖和迁移，而在模式生物中的研究表明，在胚胎发育过程中，该受体家族（PDGFRα 和 PDGFRβ）对于许多间充质和迁移细胞群体是必需的。这些迁移细胞群体之一是神经嵴，它形成颅骨和间质、交感神经元和神经节、黑素细胞和平滑肌。PDGF 信号中断的小鼠在一些神经嵴衍生物中表现出缺陷，包括腭、主动脉弓、唾液腺和胸腺。尽管这些神经嵴缺陷中的许多在多年前就被识别出来了，但 PDGF 在神经嵴中的作用机制仍存在争议。在这篇综述中，我们研究了 PDGF 在神经嵴细胞（NCC）发育过程中的作用，重点探讨了它在不同神经嵴衍生组织形成中的作用，以及 PDGF 受体在 NCC 相关人类出生缺陷中的意义。
