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扩展野调强适形放疗中蒙特卡罗剂量验证的准确性研究。

An investigation of the accuracy of Monte Carlo portal dosimetry for verification of IMRT with extended fields.

机构信息

Department of Medical Physics, Velindre Cancer Centre, Cardiff, Wales, UK.

出版信息

Phys Med Biol. 2010 Aug 21;55(16):4589-600. doi: 10.1088/0031-9155/55/16/S12. Epub 2010 Jul 29.

Abstract

This work investigated the accuracy of Monte Carlo (MC) simulations of amorphous silicon (a-Si) electronic portal imaging devices (EPIDs) for the dosimetric verification of intensity-modulated radiotherapy (IMRT). In particular, the suitability of the method for verification of head and neck IMRT with extended field segments (approximately 20 cm superior-inferior), covering almost the entire detector area, was studied. A solution involving schematic modelling of backscatter materials has been established to account for non-uniform backscatter to the imager from supporting structures. 96% of points within the IMRT fields evaluated passed a 'gamma' evaluation criterion of 2%, 2 mm at isocentre at a dose rate of 100 MU min(-1) with this solution included. Only 79% of points passed this gamma criterion without the correction for backscatter included. This work has also demonstrated the ability of the technique to detect systematic delivery errors in step and shoot IMRT. The technique identified a systematic overshoot on the first segment and an undershoot on the final segment. Results were verified by ion chamber measurements and agreed well with those reported in the literature, averaging approximately 0.1 and 0.3 MU for 100 and 300 MU min(-1) deliveries, respectively. MC portal verification has the potential to become a key tool in the verification of IMRT and can also facilitate selection of optimal delivery parameters, thus improving treatment accuracy. This approach can be applied to the verification of other new treatment techniques and should also enable development of methodologies to detect and correct for delivery errors, both before and during treatment.

摘要

这项工作研究了蒙特卡罗(MC)模拟非晶硅(a-Si)电子射野影像装置(EPID)在强度调制放疗(IMRT)剂量验证中的准确性。特别是,研究了该方法对头颈部调强放疗(约 20cm 上下)的适用性,这些调强放疗的射野范围较大,几乎覆盖整个探测器面积。为了考虑到从支撑结构到成像仪的非均匀反向散射,建立了一种涉及反向散射材料示意图建模的解决方案。在此解决方案中,96%的 IMRT 场评估点在剂量率为 100MUmin(-1)时通过了 2%、2mm 的“伽马”评估标准。如果不包括反向散射的校正,则只有 79%的点通过了该伽马标准。这项工作还证明了该技术在步进和射击 IMRT 中检测系统传输误差的能力。该技术在第一个射野段发现了系统过冲,在最后一个射野段发现了系统欠冲。结果通过离子室测量进行了验证,并与文献中报道的结果非常吻合,在 100MUmin(-1)和 300MUmin(-1)的输送中,平均误差分别约为 0.1MU 和 0.3MU。MC 端口验证有可能成为 IMRT 验证的关键工具,还可以促进最佳输送参数的选择,从而提高治疗精度。这种方法可以应用于其他新治疗技术的验证,并且还应该能够开发出在治疗前后检测和纠正输送误差的方法。

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