二氧化碳作为 C1 源在芳杂环的直接 C-H 官能化反应中的应用。

Carbon dioxide as the C1 source for direct C-H functionalization of aromatic heterocycles.

机构信息

Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland.

出版信息

Org Lett. 2010 Aug 6;12(15):3567-9. doi: 10.1021/ol101450u.

DOI:10.1021/ol101450u

PMID:20670021

Abstract

A simple and straightforward method has been developed for the direct carboxylation of aromatic heterocycles such as oxazoles, thiazoles, and oxadiazoles using CO(2) as the C1 source. The reactions require no metal catalyst and only Cs(2)CO(3) as the base. A good functional group tolerance is achieved.

摘要

已经开发出一种简单直接的方法，用于直接羧化芳香杂环，如恶唑、噻唑和恶二唑，使用 CO(2) 作为 C1 源。该反应不需要金属催化剂，只需 Cs(2)CO(3) 作为碱。实现了良好的官能团容忍度。