Department of Pathology, University of Miami-Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center, Miami, Florida, USA.
Arch Pathol Lab Med. 2010 Aug;134(8):1220-4. doi: 10.5858/2008-0679-RS.1.
Solid organ transplant-associated graft-versus-host disease is an infrequent and potentially lethal complication. The incidence of this complication varies according to the type of organ transplant with higher rates associated with liver and small bowel transplants. The clinical presentation typically includes fever and skin rash, and most cases quickly advance to become a multisystem disease affecting the bone marrow and other nontransplanted solid organs. The diagnosis is based on the clinical symptoms, pathologic changes in biopsied tissues, and systemic lymphoid chimerism. The mortality of this disease can exceed 75% after liver transplant and most patients die from infections or hemorrhage due to bone marrow failure. There is no standard treatment strategy for this complication, and the management mainly consists of both prophylaxis and immediate treatment without delay. This short review summarizes the current pathogenesis, diagnosis, and treatment of this entity.
实体器官移植相关性移植物抗宿主病是一种罕见且潜在致命的并发症。这种并发症的发生率根据器官移植的类型而有所不同，与肝和小肠移植相关的发生率更高。其临床表现通常包括发热和皮疹，大多数病例迅速进展为一种多系统疾病，影响骨髓和其他未移植的实体器官。该疾病的诊断基于临床症状、活检组织的病理变化和全身淋巴嵌合体。肝移植后该病的死亡率可超过 75%，大多数患者死于骨髓衰竭引起的感染或出血。目前尚无针对这种并发症的标准治疗策略，其治疗主要包括预防和立即治疗，不能延误。这篇简短的综述总结了该实体的当前发病机制、诊断和治疗。
