立体化学对核苷-金属碳硼烷缀合物中钠离子络合的影响。

The effect of stereochemistry on sodium ion complexation in nucleoside-metallacarborane conjugates.

机构信息

Laboratory of Molecular Virology and Biological Chemistry, Institute for Medical Biology of the Polish Academy of Sciences, Lodowa 106, 93-232 Łódź, Poland.

出版信息

Bioinorg Chem Appl. 2010;2010:196064. doi: 10.1155/2010/196064. Epub 2010 Jul 1.

DOI:10.1155/2010/196064

PMID:20671972

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2909723/

Abstract

CONJUGATES OF PURINE AND PYRIMIDINE NUCLEOSIDES

thymidine and 2'-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and (23)Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.

摘要

嘌呤和嘧啶核苷的缀合物

研究了与钴金属卡硼烷缀合的胸苷和 2'-脱氧鸟苷的钠离子络合性质。ESI-MS 光谱和 (23)Na NMR 证明了稳定的 1:1 化学计量比配合物的形成。计算了配合物形成的平衡常数和能量。核苷-金属卡硼烷缀合物与碱金属的络合可能会影响缀合物的物理化学和生物学性质，在对这些类型的修饰进行生物学评价时应加以考虑。