非小细胞肺癌术后血清血管内皮生长因子水平与血小板计数的相关性

[Correlation of postoperative serum VEGF levels with platelet counts in non-small cell lung cancer].

作者信息

Hu Ying, Li Baolan, Shi Guangli, Rong Changli, Gao Guangkuo

机构信息

Department of General, Beijing Chest Hospital, Beijing 101149, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2010 Feb;13(2):118-21. doi: 10.3779/j.issn.1009-3419.2010.02.07.

DOI:10.3779/j.issn.1009-3419.2010.02.07

PMID:20673503

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6000526/

Abstract

BACKGROUND AND OBJECTIVE

It ha been proven that serum vascular endothelial growth factor (VEGF) concentration was elevated significantly after surgery in patients of non-small cell lung cancer (NSCLC). Platelet may be the main resource of serum VEGF. The aim of this study is to investigate the correlation between postoperative dynamic changes of serum VEGF levels and platelet counts in patients of NSCLC who underwent surgery.

METHODS

Serum VEGF levels were determined in 76 patients of NSCLC who were treated with surgery by ELISA (enzyme linked immunosorbent assay) method before operation and on postoperative day 1, 7. At the same day the concentrations of platelet were determined. RESULTS (1) Serum VEGF in patients of NSCLC on preoperative day, postoperative 1 day and 7 day were (842.06 +/- 527.24) pg/mL, (1 119.28 +/- 609.62) pg/mL, (1 574.09 +/- 873.38) pg/mL, respectively (P < 0.001); (2) Platelet counts in patients of NSCLC on preoperative day, postoperative 1 day and 7 day were (230.42 +/- 82.56 x 10(9)/L, (196.47 +/- 81.48) x 10(9)/L, (237.90 +/- 86.94) x 10(9)/L; the value on postoperative 1 day was the lowest (P < 0.001); (3) On postoperative 7 day, serum VEGF in the group of lower than the mean and higher than the mean were respectively (1 398.81 +/- 734.00) pg/mL and (1 842.86 +/- 1 006.63) pg/mL (P = 0.043).

CONCLUSION

Serum VEGF in patients of NSCLC after surgery were elevated. In the group of higher platelet counts, serum VEGF increased more significantly.

摘要

背景与目的

已证实非小细胞肺癌（NSCLC）患者术后血清血管内皮生长因子（VEGF）浓度显著升高。血小板可能是血清VEGF的主要来源。本研究旨在探讨接受手术的NSCLC患者术后血清VEGF水平的动态变化与血小板计数之间的相关性。

方法

采用酶联免疫吸附测定（ELISA）法，对76例接受手术治疗的NSCLC患者术前、术后第1天和第7天的血清VEGF水平进行测定。在同一天测定血小板浓度。结果（1）NSCLC患者术前、术后第1天和第7天的血清VEGF分别为（842.06±527.24）pg/mL、（1119.28±609.62）pg/mL、（1574.09±873.38）pg/mL（P<0.001）；（2）NSCLC患者术前、术后第1天和第7天的血小板计数分别为（230.42±82.56）×10⁹/L、（196.47±81.48）×10⁹/L、（237.90±86.94）×10⁹/L；术后第1天的值最低（P<0.001）；（3）术后第7天，低于均值组和高于均值组的血清VEGF分别为（1398.81±734.00）pg/mL和（1842.86±1006.63）pg/mL（P = 0.043）。