Pakalnis A, Drake M E, Phillips B
Department of Neurology, Ohio State University College of Medicine, Columbus 43210.
Neurology. 1991 Jul;41(7):1104-6. doi: 10.1212/wnl.41.7.1104.
We studied 20 patients with continuous repetitive psychogenic seizures simulating status epilepticus. Most patients received intravenous doses of multiple anticonvulsants. Our definition used for status epilepticus was that of Delgado-Escueta et al, at least 30 minutes of repetitive seizures without regaining consciousness. Nineteen of 20 patients were young women, all but one under 40 years of age. Sixteen of these patients had a history of childhood seizures. In over 50% of patients, seizures continued until respiratory arrest and intubation occurred. Thorough neuropsychological testing and psychiatric interview were done after cessation of the acute episode. Long-term outcome and prognosis depended on definitive psychiatric diagnosis. Repetitive psychogenic seizures simulating status epilepticus are not uncommon, and such patients may incur serious iatrogenic complications from treatment for status epilepticus. Appropriate management and long-term prognosis may be determined by the type and severity of the underlying psychiatric disorder.
我们研究了20例模拟癫痫持续状态的连续性重复性心因性发作患者。大多数患者接受了静脉注射多种抗惊厥药物治疗。我们对癫痫持续状态的定义采用的是德尔加多 - 埃斯库埃塔等人的定义,即至少30分钟的重复性发作且未恢复意识。20例患者中有19例为年轻女性,除1例之外均未满40岁。这些患者中有16例有童年癫痫发作史。超过50%的患者发作持续到呼吸停止并进行插管。在急性发作停止后进行了全面的神经心理学测试和精神科访谈。长期结局和预后取决于明确的精神科诊断。模拟癫痫持续状态的重复性心因性发作并不少见,此类患者可能因癫痫持续状态的治疗而发生严重的医源性并发症。适当的管理和长期预后可能由潜在精神障碍的类型和严重程度决定。