Ageing Bone Research Program, Sydney Medical School-Nepean Campus, University of Sydney, Sydney, NSW, Australia.
Med J Aust. 2010 Aug 2;193(3):173-9. doi: 10.5694/j.1326-5377.2010.tb03839.x.
Older people living in residential aged care facilities (RACFs) are at considerably higher risk of suffering fractures than older people living in the community. When admitted to RACFs, patients should be assessed for fracture risk to ensure early implementation of effective fracture prevention measures. Routine or regular determination of calcium and phosphate serum levels in institutionalised older people is not indicated. Opinion is divided about the value of routine measurements of serum concentrations of 25-hydroxyvitamin D, parathyroid hormone and bone turnover markers. The non-pharmacological approach to fracture prevention includes multifactorial programs of falls prevention and the use of hip protectors. Vitamin D supplementation is recommended for all patients in RACFs. Dietary calcium intake should be optimised (1200-1500 mg per day is recommended) and supplementation offered to those with inadequate intake. The decision to prescribe calcium supplements should be guided by patients' tolerance, whether or not they have a history of kidney stones, and emerging data about its cardiovascular safety. Bisphosphonates are the first-choice pharmacological agents for fracture prevention in older persons at high risk. Intravenous administration is as efficient as oral and has the significant advantage of better adherence. Use of strontium ranelate has not been tested on people in RACFs, but evidence in the "old-old" (those aged 75 years and older) suggests it could be a therapeutic option for fracture prevention in this setting. In general, teriparatide should not be considered as a first-line treatment for fracture prevention, particularly for people in RACFs.
居住在养老院(RACFs)的老年人比居住在社区的老年人骨折风险高得多。当老年人入住养老院时,应评估其骨折风险,以确保尽早实施有效的骨折预防措施。没有指征常规或定期测定机构内老年人的钙和磷酸盐血清水平。关于常规测定 25-羟维生素 D、甲状旁腺激素和骨转换标志物血清浓度的价值存在分歧。骨折预防的非药物方法包括多因素跌倒预防计划和使用髋保护器。建议养老院的所有患者补充维生素 D。应优化膳食钙摄入(建议每天摄入 1200-1500 毫克),并为摄入不足的患者提供补充。是否开补钙补充剂应根据患者的耐受性、是否有肾结石病史以及关于其心血管安全性的新数据来决定。对于高风险的老年人,双膦酸盐是骨折预防的首选药物。静脉给药与口服给药同样有效,且具有更好依从性的显著优势。雷奈酸锶在养老院人群中的应用尚未经过测试,但在“老老年人”(75 岁及以上的老年人)中的证据表明,它可能是该人群骨折预防的一种治疗选择。一般来说,特立帕肽不应被视为骨折预防的一线治疗药物,尤其是对于养老院的人群。