Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan; and Chang Gung University College of Medicine, Kaohsiung.
Emerg Infect Dis. 2010 Aug;16(8):1265-72. doi: 10.3201/eid1608.091918.
Pandemic (H1N1) 2009 virus causes severe illness, including pneumonia, which leads to hospitalization and even death. To characterize the kinetic changes in viral load and identify factors of influence, we analyzed variables that could potentially influence the viral shedding time in a hospital-based cohort of 1,052 patients. Viral load was inversely correlated with number of days after the onset of fever and was maintained at a high level over the first 3 days. Patients with pneumonia had higher viral loads than those with bronchitis or upper respiratory tract infection. Median viral shedding time after the onset of symptoms was 9 days. Patients <13 years of age had a longer median viral shedding time than those >or=13 years of age (11 days vs. 7 days). These results suggest that younger children may require a longer isolation period and that patients with pneumonia may require treatment that is more aggressive than standard therapy for pandemic (H1N1) 2009 virus.
2009 年甲型 H1N1 流感大流行病毒可引起严重疾病，包括肺炎，可导致住院，甚至死亡。为了描述病毒载量的动态变化并确定影响因素，我们分析了可能影响基于医院的 1052 例患者病毒脱落时间的变量。病毒载量与发热后天数呈负相关，在最初 3 天内保持在较高水平。肺炎患者的病毒载量高于支气管炎或上呼吸道感染患者。症状发作后病毒脱落的中位时间为 9 天。<13 岁的患者中位病毒脱落时间长于≥13 岁的患者（11 天比 7 天）。这些结果表明，年龄较小的儿童可能需要更长的隔离期，肺炎患者可能需要比标准疗法更积极的治疗。
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