内皮型一氧化氮合酶（eNOS）基因第4内含子可变数目串联重复序列（VNTR）多态性的男性患原发性高血压风险高。
High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene.
作者信息
Patkar Sushma, Charita B H, Ramesh C, Padma T
机构信息
Department of Genetics, Osmania University, Hyderabad - 500 007, India.
出版信息
Indian J Hum Genet. 2009 May;15(2):49-53. doi: 10.4103/0971-6866.55215.
In this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed significantly high risk of essential hypertension for individuals who were obese, with a positive family history and with non-vegetarian food habits. Though the intron 4b/a polymorphism of eNOS gene did not reveal any association with essential hypertension in general, males with a/a genotype of the polymorphism did show significantly high risk for developing hypertension.
在本研究中，对250例原发性高血压患者进行了调查，并与218例血压正常者进行比较，以研究其与流行病学参数的相关性。其中，对176例患者和168例对照的DNA样本进行了eNOS基因第4内含子27bp重复多态性分析。研究发现，肥胖、有家族史且有非素食饮食习惯的个体患原发性高血压的风险显著增加。虽然eNOS基因第4内含子b/a多态性总体上与原发性高血压无明显关联，但具有该多态性a/a基因型的男性患高血压的风险显著增加。
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