Telomere Biology Laboratory, Cancer Research UK, London, United Kingdom.
FEBS Lett. 2010 Sep 10;584(17):3725-33. doi: 10.1016/j.febslet.2010.07.045. Epub 2010 Aug 1.
Recent years have placed fission yeast at the forefront of telomere research, as this organism combines a high level of conservation with human telomeres and precise genetic manipulability. Here we highlight some of the latest knowledge of fission yeast telomere maintenance and dysfunction, and illustrate how principles arising from fission yeast research are raising novel questions about telomere plasticity and function in all eukaryotes.
近年来,裂殖酵母成为端粒研究的前沿,因为这种生物具有高水平的保守性、与人类端粒的精确遗传可操作性。在这里,我们重点介绍了裂殖酵母端粒维持和功能障碍的最新知识,并说明了裂殖酵母研究中出现的原理如何提出关于所有真核生物中端粒可塑性和功能的新问题。