Bundeswehrzentralkrankenhaus Koblenz, Abt V HNO 56072 Koblenz, Germany.
Anticancer Res. 2010 Jul;30(7):2561-6.
Smoking and alcohol abuse cause squamous cell carcinoma of the head and neck (SCCHN) through smoke-induced mutations, which are counteracted by O(6)-methylguanine-DNA methyltransferase (MGMT). This study aimed at elucidating the role of MGMT in SCCHN and its precursor lesions (SIN). MGMT was also determined in the normal mucosa (NM) and blood lymphocytes (PBLCs).
a) MGMT was lower in NM than in PBLCs. b) Smoking reduced MGMT in NM but had no effect in PBLCs. c) MGMT activity increased in the sequence NM<SIN II and III<CIS. d) There was no correlation between MGMT and prognostic parameters or clinical course in SCCHN. The data suggest that MGMT becomes down-regulated due to smoking in non-cancerous pharyngeal mucosa. The low MGMT activity in early dysplastic mucosal lesions may increase the risk for tumour development. Since some advanced carcinomas showed low MGMT activity, chemotherapy with O(6)-alkylating agents might be an alternative option.
阐明 MGMT 在头颈部鳞状细胞癌（SCCHN）及其前体病变（SIN）中的作用。MGMT 也在正常黏膜（NM）和外周血淋巴细胞（PBLC）中进行了检测。
a）NM 中的 MGMT 低于 PBLC。b）吸烟降低了 NM 中的 MGMT，但对 PBLC 没有影响。c）MGMT 活性在 NM<SIN II 和 III<CIS 的序列中增加。d）在 SCCHN 中，MGMT 与预后参数或临床过程之间没有相关性。数据表明，MGMT 由于咽黏膜中的吸烟而下调。早期发育不良的黏膜病变中低 MGMT 活性可能会增加肿瘤发展的风险。由于一些晚期癌显示出低 MGMT 活性，因此 O（6）-烷化剂的化疗可能是一种替代选择。
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