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结直肠癌肝转移患者接受四次钇[90]微球(SIR-Spheres)治疗和同期 FOLFOX 桥接治疗后成功进行右半肝切除术。

Successful right hepatectomy after four treatments of yttrium-90 microspheres (SIR-Spheres) and concomitant FOLFOX as bridging therapy to resection of colorectal liver metastases.

机构信息

University of New South Wales, Department of Surgery, St George Hospital, Kogarah, NSW 2217, Sydney, Australia.

出版信息

Anticancer Res. 2010 Jul;30(7):3005-7.

PMID:20683046
Abstract

The use of yttrium-90 microspheres is a novel interventional radiological procedure that has delivered promising results in the treatment of liver cancer. Multiple treatments in combination with systemic chemotherapy may be realised as an effective modality for unresectable colorectal liver metastases. This case study reports the first case of a patient who had a complete response of 7 out of 10 liver metastases following multiple doses of yttrium-90 microsphere therapy, who then underwent a curative hepatic resection. This case demonstrates the feasibility and potential use of this management strategy to expand the role of successful therapies that will bridge the road towards curative liver resection.

摘要

钇 90 微球的使用是一种新型的介入放射学程序,在治疗肝癌方面取得了有希望的结果。多次治疗结合全身化疗可能成为不可切除的结直肠癌肝转移的有效治疗方法。本病例报告首例患者在多次接受钇 90 微球治疗后,10 个肝转移灶中有 7 个完全缓解,随后进行了治愈性肝切除术。该病例证明了这种管理策略的可行性和潜在用途,可以扩大成功治疗方法的作用,为治愈性肝切除术铺平道路。

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1
Successful right hepatectomy after four treatments of yttrium-90 microspheres (SIR-Spheres) and concomitant FOLFOX as bridging therapy to resection of colorectal liver metastases.结直肠癌肝转移患者接受四次钇[90]微球(SIR-Spheres)治疗和同期 FOLFOX 桥接治疗后成功进行右半肝切除术。
Anticancer Res. 2010 Jul;30(7):3005-7.
2
[A case of resection of synchronous multiple liver metastases from colorectal cancer after hepatic infusion chemotherapy and systemic chemotherapy].[1例经肝动脉灌注化疗及全身化疗后切除结直肠癌同期多发肝转移灶的病例]
Gan To Kagaku Ryoho. 2007 Sep;34(9):1481-4.
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Selective Internal Radiation Therapy (SIRT) with yttrium-90 resin microspheres plus standard systemic chemotherapy regimen of FOLFOX versus FOLFOX alone as first-line treatment of non-resectable liver metastases from colorectal cancer: the SIRFLOX study.钇-90树脂微球选择性内放射治疗(SIRT)联合FOLFOX标准全身化疗方案与单纯FOLFOX作为不可切除结直肠癌肝转移一线治疗的比较:SIRFLOX研究
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[Hepatic resection after neoadjuvant therapy for initially unresectable colorectal liver metastases].新辅助治疗后对初始不可切除的结直肠癌肝转移灶进行肝切除术
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Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy.使用钇-90微球对结直肠癌肝转移灶进行放射性栓塞,并同时进行奥沙利铂、氟尿嘧啶和亚叶酸钙全身化疗。
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Radioembolization in combination with systemic chemotherapy as first-line therapy for liver metastases from colorectal cancer.放射性栓塞联合全身化疗作为结直肠癌肝转移的一线治疗。
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Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer.钇90微球联合氟尿嘧啶/亚叶酸钙化疗与单纯氟尿嘧啶/亚叶酸钙化疗治疗晚期结直肠癌的随机2期试验
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Liver resection for colorectal liver metastases in older patients.老年患者结直肠癌肝转移的肝切除术
Crit Rev Oncol Hematol. 2008 Sep;67(3):273-8. doi: 10.1016/j.critrevonc.2008.05.003. Epub 2008 Jul 1.
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Hepatic arterial infusion chemotherapy using fluorouracil followed by systemic therapy using oxaliplatin plus fluorouracil and leucovorin for patients with unresectable liver metastases from colorectal cancer.对于无法切除的结直肠癌肝转移患者,先采用氟尿嘧啶进行肝动脉灌注化疗,随后采用奥沙利铂加氟尿嘧啶和亚叶酸钙进行全身治疗。
Cardiovasc Intervent Radiol. 2009 Jul;32(4):679-86. doi: 10.1007/s00270-009-9547-1. Epub 2009 Mar 19.

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Cancers (Basel). 2023 Jan 25;15(3):733. doi: 10.3390/cancers15030733.
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Pure laparoscopic major liver resection after yttrium radioembolization: a case-matched series analysis of feasibility and outcomes.钇 90 微球放射栓塞术后行纯腹腔镜下肝切除术:一项可行性和结局的病例匹配系列分析。
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Liver Resection After Selective Internal Radiation Therapy with Yttrium-90: Safety and Outcomes.
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J Gastrointest Oncol. 2017 Dec;8(6):1079-1099. doi: 10.21037/jgo.2017.09.10.
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