Rabasseda X
Medical Department, Thomson Reuters, Barcelona, Spain.
Drugs Today (Barc). 2010 Jul;46(7):533-42. doi: 10.1358/dot.2010.46.7.1519208.
Effective antimicrobials currently in use in Europe and throughout the world are fast losing ground as many pathogens acquire resistance to newly introduced drugs. Multidrug and panresistance have now been identified in many pathogens, as iteratively discussed throughout this year's meeting of the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). As extensively discussed in an oral session entitled Worldwide Dissemination of Resistances by 10 specialists from across Europe and the world, important drug resistances have now been identified in Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Pseudomonas aeruginosa, Acinetobacter baumanii and virtually all known pathogens (Roede, B.M. et al., Abst O127; Huenger, F. et al., Abst O395; Mera, R.M. et al., Abst O483). While many other issues were discussed, including the role of healthcare professionals and of hand hygiene in controlling the spread of infections (Derde, L. et al., Abst O464), microbial resistance was indeed the main topic of discussion in the many oral and poster presentations at the Austria Center in Vienna. The war against the superbugs has been declared and initiatives have been taken for tracking and destroying difficult to treat pathogens. Treatments of the diseases caused by these multidrug- and panresistant organisms continue, as manifested by new research and population surveys. However, with antimicrobial resistances as leitmotiv background music, other very recent scientific achievements and findings in diagnostics and treatment for infectious diseases took center stage in Vienna, including important information on novel drugs for infectious diseases and the use and comparative effectiveness of extant drugs, as summarized in the following report.
由于许多病原体对新引入的药物产生耐药性,目前在欧洲和全球使用的有效抗菌药物正在迅速失去优势。正如在今年的欧洲临床微生物学和传染病大会(ECCMID)会议上反复讨论的那样,现在已经在许多病原体中发现了多重耐药和泛耐药现象。在一场由来自欧洲和世界各地的10位专家进行的题为“耐药性的全球传播”的口头会议中进行了广泛讨论,现已在金黄色葡萄球菌、肺炎链球菌、大肠杆菌、肺炎克雷伯菌、肠炎沙门氏菌、铜绿假单胞菌、鲍曼不动杆菌以及几乎所有已知病原体中发现了重要的耐药性(罗德,B.M.等人,摘要O127;亨格,F.等人,摘要O395;梅拉,R.M.等人,摘要O483)。虽然还讨论了许多其他问题,包括医疗保健专业人员和手部卫生在控制感染传播中的作用(德德,L.等人,摘要O464),但在维也纳奥地利中心举行的许多口头报告和海报展示中,微生物耐药性确实是主要讨论话题。对抗超级细菌的战争已经打响,并且已经采取了追踪和消灭难以治疗的病原体的举措。由这些多重耐药和泛耐药生物体引起的疾病的治疗仍在继续,新的研究和人群调查就表明了这一点。然而,以抗菌药物耐药性为主题背景音乐的同时,传染病诊断和治疗方面的其他最新科学成就和发现也在维也纳成为焦点,包括有关传染病新药的重要信息以及现有药物的使用和比较效果,如下文报告所总结。