RNAi 靶向 EZH2 抑制体内胰腺癌的肿瘤生长和肝转移。

RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo.

机构信息

The Chinese University of Hong Kong, Shatin, Hong Kong.

出版信息

Cancer Lett. 2010 Nov 1;297(1):109-16. doi: 10.1016/j.canlet.2010.05.003. Epub 2010 Jun 1.

DOI:10.1016/j.canlet.2010.05.003

PMID:20684863

Abstract

The function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer.

摘要

EZH2 在胰腺癌发生和肝转移中的功能在体内从未被阐明过。EZH2 在胰腺癌中过表达，其过表达与肿瘤分化和 pT 状态有关。抑制 EZH2 导致体外胰腺癌细胞的生长明显受到抑制，并且显著降低了它们在体内的致瘤性。EZH2 的敲低抑制了体内胰腺癌的肝转移。EZH2 在胰腺癌的肿瘤生长和肝转移中起关键作用。