Patrassi G M, Sartori M T, Viero M L, Scapinello M P, Boeri G, Girolami A
Institute of Medical Semeiotics, University of Padoa Medical School, Italy.
Semin Thromb Hemost. 1991;17 Suppl 1:101-5.
Defibrotide is a polydeoxyribonucleotide salt that shows antithrombotic activity through a suggested profibrinolytic mechanism. To study the effectiveness of defibrotide in atherosclerosis, we evaluated the fibrinolytic and coagulation behavior in normal subjects and patients with atherosclerotic disease, before and after single or repeated intravenous defibrotide infusion. A significant shortening of the ELT was found in all subjects. However, since neither t-PA increase nor PAI decrease was observed, we suggest that the profibrinolytic response to defibrotide may be due to mechanisms other than t-PA stimulation. Our results provide further evidence for the usefulness of defibrotide antithrombotic prophylaxis in atherosclerosis.
去纤苷是一种多脱氧核糖核苷酸盐，通过一种推测的促纤溶机制表现出抗血栓活性。为了研究去纤苷在动脉粥样硬化中的有效性，我们评估了正常受试者和动脉粥样硬化疾病患者在单次或重复静脉输注去纤苷前后的纤溶和凝血行为。在所有受试者中均发现ELT显著缩短。然而，由于未观察到t-PA增加或PAI减少，我们认为去纤苷的促纤溶反应可能是由于t-PA刺激以外的机制。我们的结果为去纤苷抗血栓预防在动脉粥样硬化中的有用性提供了进一步的证据。
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