骨形成蛋白在癌症中的阴阳两面。
The Yin and Yang of bone morphogenetic proteins in cancer.
机构信息
Laboratory of Stem Cells and Cancer, The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
出版信息
Cytokine Growth Factor Rev. 2010 Aug;21(4):299-313. doi: 10.1016/j.cytogfr.2010.06.003. Epub 2010 Aug 4.
Abstract
Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta superfamily. These growth molecules, originally associated with bone and cartilage development, are now known to play an important role in morphogenesis and homeostasis in many other tissues. More recently, significant contributions from BMPs, their receptors, and interacting molecules have been linked to carcinogenesis and tumor progression. On the other hand, BMPs can sometimes function as a tumor suppressor. Our report highlights these new roles in the pathogenesis of cancer that may suggest novel targets for therapeutic intervention.
摘要
骨形态发生蛋白（BMPs）最初被研究为转化生长因子-β超家族的生长因子或形态发生因子。这些生长分子最初与骨骼和软骨发育有关，现在已知在许多其他组织的形态发生和动态平衡中发挥重要作用。最近，BMPs、其受体和相互作用分子的重要贡献与致癌作用和肿瘤进展有关。另一方面，BMPs 有时可以作为肿瘤抑制因子发挥作用。我们的报告强调了这些在癌症发病机制中的新作用，这可能提示了治疗干预的新靶点。
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