大鼠杏仁核中 GABA(A) ρ 受体机制及其在恐惧和焦虑调节中的作用。
GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety.
机构信息
Division of Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510, Mexico City, Mexico.
出版信息
Psychopharmacology (Berl). 2010 Dec;212(4):475-84. doi: 10.1007/s00213-010-1973-x. Epub 2010 Aug 6.
RATIONALE
Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained.
OBJECTIVES
This work was conducted to study whether GABA(A) ρ receptors may have a putative role in the amygdaloid modulation of fear and anxiety.
RESULTS
It was found that the bilateral intra-amygdaloid administration (6-240 pmol/side) of (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, a selective GABA(A) ρ receptor antagonist, reduced dose-dependently the exploration of the open arms of the elevated plus-maze without affecting locomotion and increased the plasma levels of corticosterone. In contrast, bicuculline in the dose range used (1.8-60 pmol/side) induced seizures, but had no effects on the exploration of the maze.
CONCLUSIONS
It is suggested that GABA(A) ρ receptors may have a role in the amygdaloid modulation of fear and anxiety.
原理
最近的研究结果表明，杏仁核内存在 GABA(A)ρ 受体，其亚基组成和功能特性与 GABA(A)受体家族的其他成员不同。
目的
本研究旨在探讨 GABA(A)ρ 受体是否可能在杏仁核对恐惧和焦虑的调节中发挥作用。
结果
结果发现，双侧杏仁核内给予（1,2,5,6-四氢吡啶-4-基）甲基膦酸（一种选择性 GABA(A)ρ 受体拮抗剂）（6-240 pmol/侧）可剂量依赖性地减少高架十字迷宫开臂的探索，而不影响运动，并增加血浆皮质酮水平。相比之下，在所用剂量范围内（1.8-60 pmol/侧）的荷包牡丹碱会引起癫痫发作，但对迷宫的探索没有影响。
结论
这表明 GABA(A)ρ 受体可能在杏仁核对恐惧和焦虑的调节中发挥作用。
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