Department of Cardiology, Sterling Memorial University Hospital, Medical University of Łódź, Sterlinga 1/3, Łódź, Poland.
Cardiol J. 2010;17(4):330-4.
Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde's syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias.
由于结肠血管发育不良引起的胃肠道（GI）出血可能与钙化性主动脉瓣狭窄（AS）有关。GI 血管发育不良和 AS 被定义为慢性退行性疾病，这两种疾病的患病率随着年龄的增长而增加。此外，退行性 AS 与血管性血友病因子高分子量多聚体的破坏增加有关，这可能会促进肠道血管发育不良的出血。胃肠道出血性血管发育不良和 AS 的并存已为人所知多年，被称为 Heyde 综合征。主动脉瓣置换术是晚期 AS 患者的一线治疗方法，但对并存的出血性血管发育不良和获得性血管性血友病也有效。在这项研究中，我们试图收集和系统地了解 AS 凝血异常的病因发病机制，以及 AS 合并胃肠道血管发育不良患者的诊断、临床和治疗意义。
