Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA.
J Cataract Refract Surg. 2010 Sep;36(9):1499-502. doi: 10.1016/j.jcrs.2010.04.030.
To determine the aqueous humor concentrations of moxifloxacin and besifloxacin after routine preoperative topical dosing in patients having cataract surgery.
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.
In this prospective randomized parallel double-masked clinical trial, 1 drop of commercially available moxifloxacin 0.5% ophthalmic solution or besifloxacin 0.6% ophthalmic suspension was administered every 10 minutes for a total of 4 doses beginning 1 hour before routine cataract surgery. Aqueous humor was sampled via the paracentesis, and antibiotic concentrations were determined using validated high-performance liquid chromatography procedures.
The study enrolled 50 patients. The aqueous concentration of the antibiotic agent was detectable in all 23 moxifloxacin samples and in 10 (40%) of the 25 besifloxacin samples (P<.0001, Pearson chi-square test). The mean aqueous concentration in the moxifloxacin samples was 50-fold higher than in the besifloxacin samples (1.6108 microg/mL versus 0.0319 microg/mL) when all samples were included (P<.0001, Wilcoxon test), while the moxifloxacin concentration was 38-fold higher than the besifloxacin concentration (1.6108 microg/mL versus 0.0422 microg/mL) in the samples with detectable antibiotic agent (P<.0001).
After topical preoperative administration, moxifloxacin 0.5% ophthalmic solution had a 38-fold to 50-fold higher concentration in the aqueous humor than besifloxacin 0.6% ophthalmic suspension. Besifloxacin was undetectable in more than half the aqueous humor samples.
在白内障手术患者中，确定常规术前局部滴注后莫西沙星和贝西沙星在房水中的浓度。
美国马里兰州巴尔的摩市约翰霍普金斯大学威尔默眼科研究所。
在这项前瞻性随机平行双盲临床试验中，在常规白内障手术前 1 小时开始，每 10 分钟滴入 1 滴市售的莫西沙星 0.5%眼用溶液或贝西沙星 0.6%眼用混悬液，共滴 4 滴。通过房水穿刺术取样房水，并使用经过验证的高效液相色谱程序确定抗生素浓度。
该研究纳入了 50 名患者。在所有 23 份莫西沙星样本和 10 份（40%）贝西沙星样本中均检测到抗生素的房水浓度（P<.0001，Pearson 卡方检验）。当包括所有样本时，莫西沙星样本的平均房水浓度是贝西沙星样本的 50 倍（1.6108μg/mL 与 0.0319μg/mL）（P<.0001，Wilcoxon 检验），而在可检测到抗生素的样本中，莫西沙星浓度是贝西沙星浓度的 38 倍（1.6108μg/mL 与 0.0422μg/mL）（P<.0001）。
局部术前给药后，莫西沙星 0.5%眼用溶液在房水中的浓度是贝西沙星 0.6%眼用混悬液的 38 倍至 50 倍。在超过一半的房水样本中无法检测到贝西沙星。
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