Stănescu S, Seiciu P, Popescu N
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1978 Jan-Mar;27(1):29-35.
The pulmonary function was studied in 21 patients with viral diseases of the lungs 10 to 18 days after the acute episode. In 14 cases all the parameters tested were normal; in 7 cases the alterations found led to a diagnosis of obstructive syndrome of the smaller airways (increased intrapulmonary helium mixture time, increased expired CO2 alveolar slope and residual volume). The alterations were again found on repeating the tests after 6--10 months. The various mechanisms that might cause obstruction are discussed (persistent inflammation, increased tonus of the bronchiolar musculature, hypersecretion in the smaller airways, alteration of the surfactant). In conclusion the authors raise the question of whether the obstructive alterations following pulmonary viral diseases might not be one of the etiopathogenic factors of chronic, obstructive bronchopneumopathy.
在急性发作后10至18天,对21例肺部病毒性疾病患者的肺功能进行了研究。14例患者所有检测参数均正常;7例患者所发现的改变导致诊断为小气道阻塞综合征(肺内氦气混合时间延长、呼出二氧化碳肺泡斜率增加和残气量增加)。在6至10个月后重复检测时再次发现这些改变。讨论了可能导致阻塞的各种机制(持续性炎症、细支气管肌肉组织张力增加、小气道分泌亢进、表面活性剂改变)。总之,作者提出了肺部病毒性疾病后的阻塞性改变是否可能不是慢性阻塞性支气管肺炎的病因之一的问题。