Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.
J Clin Hypertens (Greenwich). 2010 Aug;12(8):578-87. doi: 10.1111/j.1751-7176.2010.00286.x.
The authors evaluated the relationship of hypertensive target organ damage to masked hypertension assessed by ambulatory blood pressure (BP) and home blood pressure (HBP) monitoring in 129 participants without taking antihypertensive medication. Masked hypertension was defined as office BP < or =140/90 mm Hg and 24-hour ambulatory BP > or =130/80 mm Hg. The masked hypertensive participants defined by 24-hour ambulatory BP (n=13) had a higher serum glucose level (126 vs 96 mg/dL, P=.001) and urinary albumin-creatinine ratio (38.0 vs 7.5 mg/gCr, P<.001) than the normotensive participants (n=74); however, these relationships were not observed when the authors defined groups using HBP (> or =135/85 mm Hg). Masked hypertension by both 24-hour ambulatory BP and HBP had a higher urinary albumin-creatinine ratio than normotension by both 24-hour ambulatory BP and HBP (62.1 vs 7.4 mg/gCr, P=.001), and than masked hypertension by HBP alone (9.3 mg/gCr, P=.009). Masked hypertension defined by 24-hour ambulatory BP is associated with an increased serum glucose level and urinary albumin-creatinine ratio, but these relationships are not observed in masked hypertension defined by HBP.
作者评估了 129 名未服用抗高血压药物的参与者的高血压靶器官损害与动态血压(BP)和家庭血压(HBP)监测评估的隐匿性高血压之间的关系。隐匿性高血压定义为诊室血压 < =140/90mmHg 和 24 小时动态血压 > =130/80mmHg。通过 24 小时动态血压(n=13)定义的隐匿性高血压患者的血清葡萄糖水平(126 对 96mg/dL,P=.001)和尿白蛋白肌酐比值(38.0 对 7.5mg/gCr,P<.001)高于正常血压患者(n=74);然而,当作者使用 HBP(> =135/85mmHg)定义组时,未观察到这些关系。通过 24 小时动态血压和 HBP 定义的隐匿性高血压的尿白蛋白肌酐比值均高于通过 24 小时动态血压和 HBP 定义的正常血压(62.1 对 7.4mg/gCr,P=.001),并且高于仅通过 HBP 定义的隐匿性高血压(9.3mg/gCr,P=.009)。通过 24 小时动态血压定义的隐匿性高血压与血清葡萄糖水平和尿白蛋白肌酐比值升高相关,但通过 HBP 定义的隐匿性高血压则不然。