Department of Veterinary Clinical Sciences, Royal Veterinary College, North Mymms, Hatfield, UK.
J Vet Intern Med. 2010 Sep-Oct;24(5):1086-92. doi: 10.1111/j.1939-1676.2010.0566.x. Epub 2010 Jul 28.
Iatrogenic hypothyroidism can occur after treatment of hyperthyroidism, and is correlated with a reduced glomerular filtration rate in humans and dogs.
Cats with iatrogenic hypothyroidism after treatment for hyperthyroidism will have a greater incidence of azotemia than euthyroid cats.
Eighty client owned cats with hyperthyroidism.
Two retrospective studies. (1) Longitudinal study of 12 hyperthyroid cats treated with radioiodine (documented as euthyroid after treatment), to assess changes in plasma thyroid stimulating hormone (TSH) concentration over a 6-month follow-up period, (2) Cross-sectional study of 75 hyperthyroid cats (documented as euthyroid) 6 months after commencement of treatment for hyperthyroidism to identify the relationship between thyroid status and the development of azotemia. Kaplan-Meier survival analysis was performed to identify relationships between thyroid and renal status and survival.
Plasma TSH concentrations were not suppressed in 7 of 8 cats with hypothyroidism 3 months after radioiodine treatment. The proportion of cats with azotemia was significantly (P= .028) greater in the hypothyroid (16 of 28) than the euthyroid group (14 of 47). Twenty-eight of 41 cats (68%) with plasma TT4 concentration below the laboratory reference range had an increased plasma TSH concentration. Hypothyroid cats that developed azotemia within the follow-up period had significantly (P= .018) shorter survival times (median survival time 456 days, range 231-1589 days) than those that remained nonazotemic (median survival time 905 days, range 316-1869 days).
Iatrogenic hypothyroidism appears to contribute to the development of azotemia after treatment of hyperthyroidism, and reduced survival time in azotemic cats.
甲状腺功能亢进症治疗后可发生医源性甲状腺功能减退症，并且与人类和犬的肾小球滤过率降低相关。
甲状腺功能亢进症治疗后发生医源性甲状腺功能减退症的猫比甲状腺功能正常的猫发生氮质血症的几率更大。
80 只患有甲状腺功能亢进症的患宠猫。
两项回顾性研究。（1）对 12 只接受放射性碘治疗的甲状腺功能亢进症猫进行纵向研究（治疗后被记录为甲状腺功能正常），以评估在 6 个月的随访期间血浆促甲状腺激素（TSH）浓度的变化，（2）对 75 只甲状腺功能亢进症猫（治疗后被记录为甲状腺功能正常）进行横断面研究，以确定甲状腺状态与氮质血症发展之间的关系。进行 Kaplan-Meier 生存分析以确定甲状腺和肾脏状态与生存之间的关系。
在接受放射性碘治疗后 3 个月，8 只甲状腺功能减退症猫中有 7 只的血浆 TSH 浓度未被抑制。甲状腺功能减退症组（28 只中有 16 只）氮质血症的比例明显（P=.028）高于甲状腺功能正常组（47 只中有 14 只）。在 TT4 浓度低于实验室参考范围的 41 只猫中，有 28 只（68%）的血浆 TSH 浓度升高。在随访期间发生氮质血症的甲状腺功能减退症猫的生存时间明显（P=.018）缩短（中位生存时间 456 天，范围 231-1589 天），而非氮质血症猫的中位生存时间（905 天，范围 316-1869 天）更长。
甲状腺功能亢进症治疗后发生医源性甲状腺功能减退症似乎会导致甲状腺功能亢进症治疗后氮质血症的发生，并导致氮质血症猫的生存时间缩短。
Zotero 插件