Dupont Joëlle, Maillard Virginie, Coyral-Castel Stéphanie, Ramé Christelle, Froment Pascal
Unité de Physiologie de la Reproduction et des Comportements, INRA, UMR85, 37 380 Nouzilly, France.
Int J Pept. 2010;2010. doi: 10.1155/2010/158102. Epub 2010 Mar 14.
Ghrelin and one of its functional receptors, GHS-R1a (Growth Hormone Secretagogue Receptor 1a), were firstly studied about 15 years. Ghrelin is a multifunctional peptide hormone that affects several biological functions including food intake, glucose release, cell proliferation... Ghrelin and GHS-R1a are expressed in key cells of both male and female reproductive organs in several species including fishes, birds, and mammals suggesting a well-conserved signal through the evolution and a role in the control of fertility. Ghrelin could be a component of the complex series of nutrient sensors such as adipokines, and nuclear receptors, which regulate reproduction in function of the energy stores. The objective of this paper was to report the available information about the ghrelin system and its role at the level of the hypothalamic-pituitary-gonadal axis in both sexes.
大约15年前，人们首次对胃饥饿素及其一种功能性受体——生长激素促分泌素受体1a（GHS-R1a）展开研究。胃饥饿素是一种多功能肽激素，可影响多种生物学功能，包括食物摄取、葡萄糖释放、细胞增殖……在包括鱼类、鸟类和哺乳动物在内的多个物种中，胃饥饿素和GHS-R1a在雄性和雌性生殖器官的关键细胞中均有表达，这表明该信号在进化过程中得到了很好的保留，并在生育控制中发挥作用。胃饥饿素可能是一系列复杂的营养传感器（如脂肪因子和核受体）的组成部分，这些传感器根据能量储备来调节生殖功能。本文的目的是报告有关胃饥饿素系统及其在两性下丘脑-垂体-性腺轴水平上作用的现有信息。
