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一个用于管理疫苗接种计划的通用模拟模型。

A generic simulation model to manage a vaccination program.

机构信息

Department of Management, University of Tennessee-Chattanooga, Chattanooga, TN 37403-2598, USA.

出版信息

J Med Syst. 2011 Dec;35(6):1465-75. doi: 10.1007/s10916-009-9423-1. Epub 2010 Jan 29.

Abstract

The main purpose of this paper is to demonstrate how a computer model can be used as a decision making tool regarding vaccination programs. These programs include vaccination against traditional influenza, avian influenza, H1N1 (swine flu), or other diseases. Specifically, the proposed simulation model is used to investigate the impact of herd immunity, to estimate the vaccination rate for which a given disease is placed into an endemic state, and to calculate the overall cost of a vaccination program from a societal perspective. In addition, the tool can help to define an optimal vaccination rate which will result in the minimum overall cost for a vaccination program. The paper demonstrates several advantages of simulation over other decision making methods. Simulation is used to "mimic" the behavior of the disease, test a range of alternative solutions for different scenarios, and to finely adjust the model and reflect possible vaccination scenarios.

摘要

本文的主要目的是展示如何将计算机模型用作决策工具,以制定疫苗接种计划。这些计划包括预防传统流感、禽流感、H1N1(猪流感)或其他疾病的疫苗接种。具体而言,所提出的模拟模型用于研究群体免疫的影响,估计将给定疾病置于地方性状态所需的疫苗接种率,并从社会角度计算疫苗接种计划的总成本。此外,该工具可帮助定义最佳疫苗接种率,从而使疫苗接种计划的总成本最小化。本文展示了模拟相对于其他决策方法的几个优势。模拟用于“模拟”疾病的行为,测试不同场景下的一系列替代解决方案,并对模型进行微调以反映可能的疫苗接种情况。

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