Department of Neurosciences, University of Catania, Via S Sofia 78, I-95123 Catania, Italy.
Arch Gerontol Geriatr. 2011 Sep-Oct;53(2):e111-3. doi: 10.1016/j.archger.2010.07.004. Epub 2010 Aug 11.
To study whether in subcortical ischemic vascular dementia (SIVD) the changes of motor cortex excitability are due to the dementing process or to the cerebrovascular lesions, we examined 20 SIVD patients, 20 patients with subcortical ischemic disease without dementia (SIDWD) and 20 control subjects who underwent transcranial magnetic stimulation (TMS). Motor threshold (MT), amplitudes of motor evoked potentials (MEPs) and silent period (SP) were considered. MT in SIVD patients (32.7 ± 2.6%) was significantly lower (p<0.001) than in SIDWD patients (47.9 ± 3.4%) and in controls (49.1 ± 4.2%). MEP amplitude was larger in SIVD patients (6.8 ± 1.7 mV) than in the other groups (5.7 ± 1.9 mV and 5.2 ± 1.8 mV, p<0.02). Motor cortex excitability is enhanced in SIVD. Our data, taken together with previous results in Alzheimer disease (AD), indicate that motor cortex hyperexcitability is a common finding in different dementing illnesses.
为了研究皮质下缺血性血管性痴呆（SIVD）患者运动皮层兴奋性的变化是由于痴呆过程还是由于脑血管病变引起的，我们检查了 20 例 SIVD 患者、20 例无痴呆的皮质下缺血性疾病（SIDWD）患者和 20 例对照组，这些患者接受了经颅磁刺激（TMS）检查。考虑了运动阈值（MT）、运动诱发电位（MEP）幅度和静息期（SP）。SIVD 患者的 MT（32.7 ± 2.6%）明显低于 SIDWD 患者（47.9 ± 3.4%）和对照组（49.1 ± 4.2%）（p<0.001）。SIVD 患者的 MEP 幅度较大（6.8 ± 1.7 mV），而其他组的 MEP 幅度较小（5.7 ± 1.9 mV 和 5.2 ± 1.8 mV，p<0.02）。SIVD 患者运动皮层兴奋性增强。我们的数据与之前阿尔茨海默病（AD）的结果一起表明，运动皮层兴奋性过高是不同痴呆疾病的共同发现。
