Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
J Org Chem. 2010 Sep 17;75(18):6173-81. doi: 10.1021/jo101004x.
A highly enantio- and diastereoselective Lewis acid catalyzed S(N)2-type ring opening followed by cyclization of aziridines with active methylene carbon nucleophiles to functionalized chiral γ-lactams in a domino fashion has been developed. γ-Lactams have been desulfonated and decarboxylated, providing pyrrolidone-3-carboxylate and N-tosylpyrrolidinone derivatives, respectively, in good yields.
已开发出一种高对映选择性和非对映选择性路易斯酸催化的 S(N)2 型环开环，随后与活泼亚甲基碳亲核试剂进行环化反应，以顺式方式构建功能化的手性 γ-内酰胺的多米诺反应。γ-内酰胺进行脱磺化和脱羧反应，分别以良好的产率提供吡咯烷酮-3-羧酸酯和 N-对甲苯磺酰基吡咯烷酮衍生物。
