肌肉内和静脉内左乙拉西坦在人体中的安全性和药代动力学。
Intramuscular and intravenous levetiracetam in humans: safety and pharmacokinetics.
机构信息
University of Minnesota, Minneapolis, MN 55455, United States; MINCEP Epilepsy Care, Minneapolis, MN 55416, United States.
出版信息
Epilepsy Res. 2010 Oct;91(2-3):289-92. doi: 10.1016/j.eplepsyres.2010.07.016. Epub 2010 Aug 14.
Abstract
A study in dogs demonstrated that the commercially available formulation of IV levetiracetam (LEV) could be given safely IM and was quickly and completely absorbed. In this crossover study, 5 women and 5 men were given IM and IV LEV. This study demonstrates that administration of 5ml (500mg) IM LEV is well tolerated and its bioavailability is equivalent to an IV injection.
摘要
一项在犬类中进行的研究表明，市售的 IV 左乙拉西坦（LEV）制剂可安全地肌内注射，且吸收迅速且完全。在这项交叉研究中，5 名女性和 5 名男性接受了肌内注射和静脉注射 LEV。这项研究表明，给予 5ml（500mg）肌内注射 LEV 是可耐受的，其生物利用度与静脉注射相当。
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