中文译文：中国勃起功能障碍患者的戒烟和遵医行为干预。

Smoking-cessation and adherence intervention among Chinese patients with erectile dysfunction.

机构信息

Department of Nursing Studies, The University of Hong Kong, Hong Kong.

出版信息

Am J Prev Med. 2010 Sep;39(3):251-8. doi: 10.1016/j.amepre.2010.05.006.

DOI:10.1016/j.amepre.2010.05.006

PMID:20709257

Abstract

BACKGROUND

Whether the association between smoking and erectile dysfunction is causal is uncertain. No RCTs have been previously conducted on cessation counseling and additional nicotine replacement therapy (NRT) adherence counseling among smokers with erectile dysfunction.

PURPOSE

The aim of the study was to determine if smoking-cessation counseling in conjunction with NRT increases quitting and NRT adherence compared to usual care, and if stopping smoking would improve erectile function among Chinese erectile dysfunction patients who smoke.

DESIGN

An RCT was conducted. Data were collected in 2004-2007 and analyzed in 2008.

SETTING/PARTICIPANTS: The sample included 719 Chinese adult erectile dysfunction patients who smoked at least 1 cigarette per day, intended to quit smoking within the next 7 days, and would use NRT.

INTERVENTIONS

Group A1 received 15-minute smoking-cessation and 3-minute NRT adherence counseling at baseline, 1 week, and 4 weeks with free NRT for 2 weeks. Group A2 received the same treatment, except for the adherence counseling. Group B received 10 minutes of quitting advice. All subjects received a self-help quitting booklet at first contact.

MAIN OUTCOME MEASURES

Self-reported 7-day tobacco abstinence at 6 months, 4-week NRT adherence at 1 month, and improvement in erectile dysfunction condition at 6 months.

RESULTS

The intervention groups (A1+A2) achieved higher rates of abstinence, both self-reported (23% vs 12.8%, RR=1.79, 95% CI=1.22, 2.62) and biochemically validated (11.4% vs 5.5%, RR=2.07, 95% CI=1.13, 3.77), than the control group. The NRT adherence rate did not differ between Groups A1 and A2 (13.7% vs 12.7%, RR=1.08, 95% CI=0.69, 1.69). An improvement in erectile dysfunction status from baseline to 6 months was associated with self-reported quitting at 6 months but not with intervention status.

CONCLUSIONS

Although quitting smoking was associated with improvement in erectile dysfunction, this study found significant outcome differences among the means used to achieve smoking cessation.

TRIAL REGISTRATION

ISRCTN13070778.

摘要

背景

吸烟与勃起功能障碍之间的关联是否具有因果关系尚不确定。以前没有进行过关于勃起功能障碍吸烟者的戒烟咨询和额外的尼古丁替代疗法（NRT）依从性咨询的随机对照试验。

目的

本研究旨在确定与常规护理相比，戒烟咨询联合 NRT 是否会增加戒烟和 NRT 依从性，以及停止吸烟是否会改善中国勃起功能障碍吸烟者的勃起功能。

设计

进行了一项随机对照试验。数据收集于 2004-2007 年，分析于 2008 年进行。

地点/参与者：该样本包括 719 名中国成年勃起功能障碍吸烟者，他们每天至少吸 1 支香烟，打算在未来 7 天内戒烟，并将使用 NRT。

干预措施

A1 组在基线、1 周和 4 周时接受 15 分钟的戒烟和 3 分钟的 NRT 依从性咨询，并在 2 周内免费提供 NRT。A2 组接受了相同的治疗，但没有接受依从性咨询。B 组接受了 10 分钟的戒烟建议。所有患者在首次接触时均收到一本自助戒烟手册。

主要观察指标

6 个月时的 7 天烟草禁欲率、1 个月时的 4 周 NRT 依从率和 6 个月时的勃起功能障碍改善情况。

结果

干预组（A1+A2）的戒烟率均高于对照组，包括自我报告（23%比 12.8%，RR=1.79，95%CI=1.22，2.62）和生物验证（11.4%比 5.5%，RR=2.07，95%CI=1.13，3.77）。A1 组和 A2 组的 NRT 依从率无差异（13.7%比 12.7%，RR=1.08，95%CI=0.69，1.69）。从基线到 6 个月时勃起功能障碍状况的改善与 6 个月时的自我报告戒烟相关，但与干预状态无关。