Yoneyama Kimiyasu, Hata Keisuke, Kanamoto Akira, Tsurita Giichirou, Ito Akihiko, Shinozaki Masaru, Tahara Hideaki
Dept. of Surgery, Hospital of the Institute of Medical Science, University of Tokyo.
Gan To Kagaku Ryoho. 2010 Aug;37(8):1561-3.
Reported is a case of advanced accessory breast cancer to which weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide proved very effective. The patient was a 49-year-old woman who noticed a tumor in the right axilla around October 2007 but then left it alone. In October 2008, the patient visited a nearby physician who made a diagnosis of locally advanced accessory breast cancer. Because the tumor enlarged despite endocrinotherapy, the patient was referred to our hospital in July 2009. CT scan showed a tumor with a size of infant's head, multiple lymph node metastases and metastases to the skin, liver and bones. Following weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide for 4 months, the tumor in the right axilla and metastases to the lymph nodes, skin and liver disappeared. Adverse events were alopecia and grade 1 peripheral neuropathy. The treatment continues at present. Weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide has few adverse reactions and can be performed at an outpatient clinic, suggesting that it is a useful treatment.
报告了一例晚期副乳腺癌病例,每周注射紫杉醇加每周口服环磷酰胺被证明非常有效。患者为一名49岁女性,2007年10月左右发现右腋窝有一个肿块,但未予理会。2008年10月,患者就诊于附近医生,被诊断为局部晚期副乳腺癌。尽管进行了内分泌治疗,肿瘤仍增大,患者于2009年7月转诊至我院。CT扫描显示一个婴儿头大小的肿瘤,伴有多处淋巴结转移以及皮肤、肝脏和骨骼转移。在每周注射紫杉醇加每周口服环磷酰胺4个月后,右腋窝的肿瘤以及淋巴结、皮肤和肝脏的转移灶消失。不良事件为脱发和1级周围神经病变。目前治疗仍在继续。每周注射紫杉醇加每周口服环磷酰胺不良反应少,可在门诊进行,表明这是一种有效的治疗方法。