Department of Obstetrics and Gynaecology, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.
Neurogastroenterol Motil. 2010 Dec;22(12):1279-83. doi: 10.1111/j.1365-2982.2010.01576.x. Epub 2010 Aug 16.
Functional gastrointestinal disorders or 'functional gastrointestinal disorder-like' symptoms (FGIDs) occur commonly in eating disorders (ED), but it is not known if these disorders are stable over time. The aims were to evaluate the turnover of FGIDs in patients with ED, and to relate this turnover to changes in body mass index (BMI), ED behaviors, and psychological variables.
Patterns and repeated measures analysis of presence of individual FGIDs and regional FGID categories (esophageal, gastroduodenal, bowel, and anorectal) in ED patients (n = 73) at admission to hospital and at 12-month follow-up, using change in BMI and ED behaviors as between patient variables.
Functional gastrointestinal disorders prevalence was 97% at admission and 77% at follow-up. The only individual FGIDs to decrease over time were functional heartburn (admission 53%, follow-up 23%) and functional dysphagia (21%, 7%). There was significant patient variation in the disappearance, persistence, and appearance of both individual FGIDs and FGID regional categories. Twenty-five (34%) of patients acquired at least one new FGID regional category at follow-up. There was no relationship between changes in BMI, self-induced vomiting, laxative use, binge eating, anxiety, depression, somatization, and the turnover of individual or regional FGIDs.
CONCLUSIONS & INFERENCES: Functional gastrointestinal disorders remain common after 12 months in patients with an ED. Considerable turnover of the FGIDs occurs, however, and the appearance of new FGIDs is not restricted to the original FGID regional category. There is no apparent relationship between the turnover of the FGIDs and ED behaviors, psychological variables or body weight change. These findings have implications for the clinical evaluation and management of FGIDs in ED patients.
功能性胃肠病或“功能性胃肠病样”症状（FGIDs）在进食障碍（ED）中很常见，但这些疾病是否随时间稳定尚不清楚。目的是评估 ED 患者 FGIDs 的变化，并将其与 BMI、ED 行为和心理变量的变化相关联。
采用个体 FGIDs 和区域性 FGID 类别（食管、胃十二指肠、肠道和肛门直肠）的模式和重复测量分析，评估 ED 患者（n=73）入院时和 12 个月随访时 FGIDs 的存在，使用 BMI 和 ED 行为的变化作为患者间变量。
入院时 FGIDs 的患病率为 97%，随访时为 77%。唯一随时间减少的个体 FGIDs 是功能性烧心（入院时 53%，随访时 23%）和功能性吞咽困难（21%，7%）。个体 FGIDs 和 FGID 区域性类别的消失、持续和出现存在显著的患者间差异。25（34%）例患者在随访时至少出现了一个新的 FGID 区域性类别。BMI、自我诱导呕吐、泻药使用、暴食、焦虑、抑郁、躯体化和个体或区域性 FGIDs 的变化之间没有关系。
ED 患者在 12 个月后仍常见 FGIDs。然而，FGIDs 的变化相当大，新 FGIDs 的出现不限于原始 FGID 区域性类别。FGIDs 的变化与 ED 行为、心理变量或体重变化之间似乎没有明显关系。这些发现对 ED 患者 FGIDs 的临床评估和管理具有重要意义。
