Grant Philip M, Zolopa Andrew R
Stanford University, 300 Pasteur Drive, Room S-101, Stanford, CA 94305-5107, USA.
Curr Opin Investig Drugs. 2010 Aug;11(8):901-10.
Potent antiretroviral therapy (ART) has transformed HIV infection into a chronic manageable disease, but drug resistance remains a common problem that limits the effectiveness and clinical benefits of treatment. With increasing experience with ART, the understanding of viral dynamics of HIV improved, and researchers learned how challenging HIV can be to control. With new-class and new-generation drugs, it is hoped that the lessons learned will be useful for limiting drug resistance and optimizing the use of ART for long-term management of HIV infection.
强效抗逆转录病毒疗法（ART）已将艾滋病毒感染转变为一种可慢性控制的疾病，但耐药性仍然是一个常见问题，限制了治疗的有效性和临床益处。随着对ART经验的增加，对艾滋病毒病毒动力学的理解得到了改善，研究人员了解到控制艾滋病毒具有多大的挑战性。有了新型和新一代药物，希望所吸取的经验教训将有助于限制耐药性，并优化ART在艾滋病毒感染长期管理中的使用。
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