Wichert G von, Adler G, Seufferlein T
Innere Medizin I, Universität Ulm.
Dtsch Med Wochenschr. 2010 Aug;135(34-35):1687-91. doi: 10.1055/s-0030-1262461. Epub 2010 Aug 18.
The aim of palliative chemotherapy is to increase survival whilst maintaining optimal quality of life for the individual patient. While the best use of traditional chemotherapeutical agents continues to be explored, the introduction of targeted therapies has significantly broadened the therapeutic options. Yet it is interesting to note that the results of current trials did not always confirm the underlying molecular concepts. Recent data have suggested that altered pathways underlie the development of cancer, not just altered genes. Thus an effective therapeutic agent will have to target pathophysiologically relevant signalling networks, rather than individual proteins. This review presents current concepts and problems of cancer treatment, highlighting results from recent clinical trials of colorectal and pancreatic cancer patients and to discuss the current understanding of the underlying mechanisms.
姑息性化疗的目的是在维持个体患者最佳生活质量的同时延长生存期。在不断探索传统化疗药物最佳使用方法的同时，靶向治疗的引入显著拓宽了治疗选择。然而，值得注意的是，当前试验结果并非总能证实潜在的分子概念。最近的数据表明，癌症的发生不仅仅是基因改变，改变的信号通路才是其发病基础。因此，一种有效的治疗药物必须针对病理生理学相关的信号网络，而不是单个蛋白质。本综述介绍了癌症治疗的当前概念和问题，重点强调了近期结直肠癌和胰腺癌患者临床试验的结果，并讨论了对潜在机制的当前理解。
