Le Jennifer, San Agustin Michael, Hernandez Elvin A, Tran Tu T, Adler-Shohet Felice C
University of California San Diego, La Jolla, USA.
Clin Pediatr (Phila). 2010 Nov;49(11):1038-43. doi: 10.1177/0009922810374210. Epub 2010 Aug 19.
The authors sought to determine the prevalence, risk factors, and clinical impact of complications associated with outpatient parenteral antimicrobial therapy (OPAT) in children.
A cohort of patients ≤18 years old with infections, who received OPAT were evaluated retrospectively. Antibiotic-associated complications (AACs), catheter-associated complications (CACs), and unplanned medical care visits were the main outcome measures.
Overall, 36 complications (25 CACs and 11 AACs) occurred in 32 of 98 patients. Mean age of patients, race, gender, and infecting organism did not differ between study groups. The use of OPAT for osteomyelitis was associated with complications (odds ratio = 2.69; 95% confidence interval = 0.99-7.35; P = .05). All patients, except for 4 who had complications, clinically improved by the end of OPAT. Unplanned medical visits occurred in 17 patients, 15 of which were because of CACs.
Complications occurred commonly in children receiving OPAT and resulted in unplanned medical visits.
作者试图确定儿童门诊胃肠外抗菌治疗（OPAT）相关并发症的发生率、危险因素及临床影响。
回顾性评估一组年龄≤18岁接受OPAT治疗的感染患者。抗生素相关并发症（AACs）、导管相关并发症（CACs）及非计划医疗就诊为主要观察指标。
98例患者中，32例共发生36例并发症（25例CACs和11例AACs）。研究组间患者的平均年龄、种族、性别及感染病原体无差异。OPAT用于骨髓炎治疗与并发症相关（比值比=2.69；95%置信区间=0.99 - 7.35；P = 0.05）。除4例出现并发症的患者外，所有患者在OPAT结束时临床症状均有改善。17例患者出现非计划医疗就诊，其中15例是由于CACs。
接受OPAT治疗的儿童常见并发症，且导致非计划医疗就诊。
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