腔内放射治疗与同步氟尿嘧啶输注在食管癌治疗中的作用：一项初步研究。
The role of intraluminal radiotherapy and concurrent 5-fluorouracil infusion in the management of carcinoma esophagus: a pilot study.
作者信息
Dinshaw K A, Sharma V, Pendse A M, Telang C S, Vege S S, Malliat M K, Deshpande R, Desai P B
机构信息
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Bombay, India.
出版信息
J Surg Oncol. 1991 Jul;47(3):155-60. doi: 10.1002/jso.2930470304.
Fifty patients with carcinoma of the esophagus were entered in a randomized pilot study to test the efficacy of intraluminal radiotherapy (ILRT) and concurrent 5-fluorouracil (5-FU) infusion. The median age was 65 years, with 80% having middle third lesions; in 62%, the lesions were longer than 5 cm. After external beam therapy of 50 Gy in 5 weeks, patients were randomized to receive chemotherapy. Significant improvement in dysphagia was recorded in 76% patients with complete response in 47 cases ranging from 6 to 27 months. The overall survival at 2 years was 15% with ILRT alone versus 22% with ILRT plus 5-FU infusion.
五十例食管癌患者进入一项随机试验性研究，以测试腔内放射治疗（ILRT）和同步5-氟尿嘧啶（5-FU）输注的疗效。中位年龄为65岁，80%的患者病变位于食管中段；62%的患者病变长度超过5cm。在5周内接受50Gy的外照射治疗后，患者被随机分组接受化疗。76%的患者吞咽困难有显著改善，47例患者完全缓解，缓解持续时间为6至27个月。单纯ILRT组2年总生存率为15%，ILRT加5-FU输注组为22%。
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