创伤性脑损伤相关的垂体功能减退症：对参战退伍军人筛查的综述与建议

Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans.

作者信息

Guerrero Arthur F, Alfonso Abel

机构信息

Endocrinology, Diabetes, and Metabolism Service, Department of Internal Medicine, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, DC 20307, USA.

出版信息

Mil Med. 2010 Aug;175(8):574-80. doi: 10.7205/milmed-d-09-00189.

DOI:10.7205/milmed-d-09-00189

PMID:20731261

Abstract

Recent civilian data obtained in those sustaining head injuries, has found a high prevalence of pituitary dysfunction. Currently, there is no data available in the military population. We reviewed the literature for traumatic brain injury (TBI)-related hypopituitarism and found that the prevalence of anterior hypopituitarism may be as high as 30-80% after 24-36 months. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important to make clinicians caring for combat veterans aware of its occurrence. Herein, we provide an overview of the literature and recommendations for hormonal testing when TBI-related hypopituitarism is suspected.

摘要

最近在头部受伤患者中获得的平民数据显示，垂体功能障碍的患病率很高。目前，军事人群中尚无相关数据。我们查阅了有关创伤性脑损伤（TBI）相关垂体功能减退的文献，发现24至36个月后，垂体前叶功能减退的患病率可能高达30%-80%。由于垂体功能减退的许多症状与TBI相似，因此让照顾退伍军人的临床医生了解其发生情况很重要。在此，我们概述了相关文献，并针对怀疑TBI相关垂体功能减退时的激素检测提出建议。