Wessex Cardiothoracic Centre, Southampton University Hospitals, Southampton, United Kingdom.
Ann Thorac Surg. 2010 Sep;90(3):830-7. doi: 10.1016/j.athoracsur.2010.03.108.
The purpose of this study was to analyze the factors affecting reoperation after primary biventricular atrioventricular septal defect (AVSD) repair.
Between April 1997 and April 2007, 93 consecutive patients underwent surgery for biventricular correction of AVSD with a median age of 5.8 months (range, 9 days to 68.9 years). Fifty-three patients had complete AVSD, 6 patients had an intermediate type, and 29 patients had partial AVSD; 4 patients had a complete AVSD with associated tetralogy of Fallot, and 1 patient had a complete AVSD with double-outlet right ventricle.
There was no in-hospital mortality. There were 2 late deaths (2.2%). Forty-three reoperations were performed in 23 patients (24.7%), of which 18 were for repair of significant left atrioventricular valve regurgitation and 8 were mitral valve replacements. Seven patients (7.5%) required insertion of a permanent pacemaker. The overall 5-year freedom from reoperation after AVSD repair was 73.6% +/- 4.8%. In the multivariate analysis for complete AVSDs, Down syndrome (p = 0.01) and the presence of right ventricular dominance (p = 0.03) were independent predictors of reoperation. At last follow-up, 76 patients (83.5%) were in New York Heart Association class I, and 68 patients (74.7%) were not taking any heart failure medications. Echocardiographic examination showed absent to mild left atrioventricular valve regurgitation in 76.5%; moderate, in 19.8%; and severe, in 3.7% of patients.
Down syndrome and right ventricular dominance are independent predictors of reoperation after complete AVSD repair. Biventricular repair of isolated AVSD with a small left ventricle can be successfully accomplished with no mortality.
本研究旨在分析影响原发双心室房室间隔缺损(AVSD)修复后再次手术的因素。
1997 年 4 月至 2007 年 4 月,93 例连续患者接受了双心室矫正 AVSD 的手术治疗,中位年龄为 5.8 个月(范围为 9 天至 68.9 岁)。53 例患者有完全型 AVSD,6 例为中间型,29 例为部分型 AVSD;4 例患者有完全型 AVSD 合并法洛四联症,1 例患者有完全型 AVSD 合并双出口右心室。
无院内死亡。有 2 例患者死于晚期(2.2%)。23 例患者中有 43 例(24.7%)接受了再次手术,其中 18 例为修复严重的左房室瓣反流,8 例为二尖瓣置换术。7 例(7.5%)需要植入永久性起搏器。AVSD 修复后 5 年免于再次手术的总体生存率为 73.6% +/- 4.8%。在完全型 AVSD 的多变量分析中,唐氏综合征(p = 0.01)和右心室优势(p = 0.03)是再次手术的独立预测因素。最后一次随访时,76 例(83.5%)患者为纽约心脏协会心功能分级 I 级,68 例(74.7%)患者未服用任何心力衰竭药物。超声心动图检查显示,76.5%的患者左房室瓣反流为无至轻度;19.8%为中度;3.7%为重度。
唐氏综合征和右心室优势是完全型 AVSD 修复后再次手术的独立预测因素。对于伴有小左心室的孤立性 AVSD,可成功进行双心室修复,无死亡率。